Glycosaminoglycans and diabetic nephropathy
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چکیده
منابع مشابه
SCIENCE WATCH Glycosaminoglycans: Use in Treatment of Diabetic Nephropathy
Because diabetic nephropathy occurs in 20 to 40% of patients with diabetes mellitus, it has become one of the most important causes of end-stage renal disease. The latest incidence figures vary from 16% of patients starting with dialysis in The Netherlands (1) to 42% in the United States (2). Diabetic nephropathy has a large impact in terms of associated morbidity and mortality for the individu...
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Diabetes is a disease that is present worldwide and which is associated with a large number of potential complications including chronic kidney disease (CKD). Several factors have been implicated in the development of the latter, including advanced glycation end-products (AGEs), which are formed from the interaction between sugar and proteins. AGE toxicity may be triggered via different mechani...
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Decreased expression of heparan sulphate has been shown in the glomerular basement membrane of patients with over diabetic nephropathy. Low- molecular-weight heparin (LMWH) is a highly sulphated glycosaminoglycan with strong structural and functional similarities to heparan sulphate. In a first study, we set out to assess if LMWH could decrease the urinary albumin excretion rate (AER) in diabet...
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Hypothesis Implication for health policy/practice/research/medical education: The combination of metformin and ginger extract may be more effective for the control of diabetes and may have additive protective efficacy on diabetic nephropathy. N ephropathy of the diabetes is one of the most important complications of this illness. Recently, much attention has been made toward the possible kidney...
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CONTEXT Oxidative stress has crucial role in pathogenesis of diabetic nephropathy (DN). Despite satisfactory results from antioxidant therapy in rodent, antioxidant therapy showed conflicting results in combat with DN in diabetic patients. EVIDENCE ACQUISITIONS Directory of Open Access Journals (DOAJ), Google Scholar,Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. RESULTS...
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ژورنال
عنوان ژورنال: Problems of Endocrinology
سال: 2004
ISSN: 2308-1430,0375-9660
DOI: 10.14341/probl11392